Life goes on after the tragic events at the end of Season 1 in this Season Two opener, though Dr. Orpheus seems to be taking it particularly hard. Meanwhile, the Monarch deals with life "inside."
Things return to normal in the lives of the Ventures. The Monarch confronts Dr. Girlfriend in a mall food court while his new henchmen stumble upon the Venture family shopping.
When Brock is asked by the Office of Secret Intelligence to track down a rogue agent, he makes a deal with the mercenary Molotov Cocktease to protect the Venture Compound from enemies within and without during his absence. While Hank becomes enamored with Molotov, Brock discovers he must hunt down his mentor General Hunter Gathers. "Assassinanny 911" is chronologically after Victor Echo November.
Team Venture find themselves trapped in the clutches of a bloodthirsty Egyptian cult and their time machine. Doc narrowly escapes, but promptly forgets to mount a rescue while entering a contest with Doctor Orpheus. So it's up to Brock and a pantheon of history's greatest men to find another way out.
In the middle of spring cleaning, Brock's discovery of a lost videotape from Jonas Venture Sr. sets Team Venture off on a global scavenger hunt for the hidden pieces of a fantastic and potentially deadly machine. But to save humanity from a terrible fate, they'll have to overcome death, drug addiction, Jonny Quest and Professor Impossible--all under the watchful eye of the mysterious Grand Galactic Inquisitor.
Hank and Dean go on a double date with Triana and her friend Kim, while the Phantom Limb and Dr. Girlfriend agree to a double date with The Monarch and some girl he met "on the LiveJournal" in order to discuss the Monarch's official re-entry into the Guild of Calamitous Intent, all in the same restaurant. Tempers flare, and Doc and Brock become the unwitting pawns in a low-grade pissing contest when Phantom Limb sets the Guild's commandos on the Venture family to prove his dominance.
On their way home from a Halloween costume party, the Ventures crash land in Ünderland. Baron Ünderbheit captures them, obsessed with taking revenge on Dr. Venture, but mistakes Dean for a girl and attempts to make him the 8th Baroness of Ünderland. Meanwhile, Brock, Hank, and Dr. Venture are rescued by Catclops and Girl Hitler's underground resistance group, the Ünderground.
When the Guild of Calamitous Intent finally approves Dr. Orpheus for his very own arch-nemesis, he calls upon his old friends Jefferson Twilight and the Alchemist to resurrect their former super-team: the Order of the Triad.
When the Gargantua-1 Space Station breaks orbit and crashes into a number of wanted terrorists, Colonel Bud Manstrong becomes a national hero. But did it really happen, or is Bud's mother, the indomitable Mrs. Manstrong, behind an insidious plot to assassinate the President? The mysterious blinking bandage on Bud's neck might be the key to a mystery only the ghost of Abraham Lincoln and the Venture Brothers can solve.
The Monarch continues to rebuild his villainous empire with the aid of his shadowy new Number 2, Dr. Henry Killinger, but #21 is suspicious of the good Doctor's unctuous charms. Meanwhile, as Dr. Orpheus attempts to exorcise a Japanese demon from Dr. Venture, the boys are kidnapped by a mysterious woman from Doc's past.